This emphasizes the need for judicious selection of patients for antibiotic therapy.
At this level, the risk of antibiotic toxicity may overshadow the benefits of antibiotic therapy.
Ann int Med 1972, 77: 701-706.
The panel agreed that this approach was an appropriate balance between the competing goals of providing early appropriate antibiotic coverage to improve clinical outcomes such as mortality while avoiding superfluous treatment that may lead to antibiotic resistance, side effects, and increased cost.
Clin infect Dis 2010, 1: S131-S135.
The studies identified had inconsistent results.